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Anti-cancer initiatives

Anti-cancer initiatives

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Anti-cancer initiatives -

In particular, there was significantly less endometrial cancer with raloxifene use. November 10, —Researchers discovered mutations in a particular gene that affects the treatment prognosis for some patients with acute myeloid leukemia, an aggressive blood cancer that kills 9, Americans annually.

December 23, —NCI announced major changes to the long-established Clinical Trials Cooperative Group Program that conducts many of the nationwide trials of new cancer therapies. In a major transformation, NCI intends to consolidate the nine groups that currently conduct trials in adult cancer patients into four state-of-the-art entities that will design and perform improved trials of cancer therapies.

The changes are designed to provide greater benefits for cancer patients and more information for researchers. These moves come in response to an NCI-requested April report from the Institute of Medicine, which called for a series of changes to the cooperative groups program, including restructuring.

The NCI Cooperative Group program, founded over 50 years ago, involves more than 3, institutions and 14, investigators, and the program enrolls over 25, patients in clinical trials each year.

March 10, —The number of cancer survivors in the United States increased to There were 3 million cancer survivors in and 9. March 31, —Rates of death in the United States from all cancers for men and women continued to decline between and , the most recent reporting period available, according to the latest Annual Report to the Nation on the Status of Cancer.

June 5, —NCI announced clinical trial results showing that in a high-risk form of pediatric acute lymphoblastic leukemia, a high-dose schedule of a drug raises already high cure rates even higher.

June 29, —An analysis of genomic changes in ovarian cancer has provided the most comprehensive and integrated view of cancer genes for any cancer type to date. Ovarian serous adenocarcinoma tumors from patients were examined by The Cancer Genome Atlas TCGA Research Network.

TCGA researchers completed whole-exome sequencing, which examines the protein-coding regions of the genome, on an unprecedented tumors. September, 8, —The NCI-sponsored Costa Rica Vaccine Trial was designed to assess the efficacy of Cervarix in a community-based setting.

Two doses of the human papillomavirus vaccine HPV Cervarix were as effective as the current standard three-dose regimen after four years of follow-up. January 19, —A clinical trial has shown that addition of chemotherapy to radiation therapy leads to a near doubling of median survival time in patients with a form of brain tumor oligodendroglioma that carries a chromosomal abnormality called the 1p19q co-deletion.

March 2, —The Diesel Exhaust in Miners Study looked at 12, workers at 8 non-metal mining facilities in the United States. Federal government scientists reported that heavy exposure to diesel exhaust increased risk of death from lung cancer.

March 8, —In a new examination of United States cancer incidence data, investigators reported that incidence trends have remained roughly constant for glioma, the main type of brain cancer hypothesized to be related to cell phone use.

May 21, — In a study that spanned 20 years, the Prostate, Lung, Colorectal, and Ovarian PLCO Cancer Screening Trial, sponsored by NCI, found that sigmoidoscopy is effective in reducing the rates of new cases and deaths due to colorectal cancer.

September 27, —Scientists may have discovered why a protein called MYC can provoke a variety of cancers. Like many proteins associated with cancer, MYC helps regulate cell growth. A study carried out by researchers at NIH and colleagues found that, unlike many other cell growth regulators, MYC does not turn genes on or off, but instead boosts the expression of genes that are already turned on.

More than 30 percent of all human cancers are driven by mutations of the RAS family of genes. This approach is called a "hub and spoke" model. The Frederick National Laboratory for Cancer Research FNLCR acts as the hub that connects to the larger community of RAS researchers around the world combining efforts and creating new ways to approach the complex issue of RAS.

September 19, —A world-wide competition to bring emerging breast cancer technologies to market was launched by the Avon Foundation for Women, in partnership with NCI and the Center for Advancing Innovation.

Teams were offered the opportunity to create strategic business plans and the potential to start new companies based on the development of 10 unlicensed breast cancer inventions by turning them into commercially marketed products.

Breast cancer inventions include therapeutics, diagnostics, prognostics, one device, one vaccine, and a health IT invention, all from the NCI intramural Center for Cancer Research and Avon Foundation-funded university labs. October 10, —Glioblastoma multiforme GBM was the first cancer type to be systematically studied by The Cancer Genome Atlas Research Network TCGA in In a new, complementary report, TCGA experts examined more than GBM samples—the largest to date utilizing genomic characterization techniques and nearly more than were examined in —to identify several additional significantly mutated genes in GBM.

November 13, —A trial conducted by researchers at NCI showed adult patients with a type of cancer known as Burkitt lymphoma had excellent long-term survival rates—upwards of 90 percent—following treatment with low-intensity chemotherapy regimens.

Standard treatment for Burkitt lymphoma involves high-dose chemotherapy, which has a high rate of toxicity, including death, and cures only 60 percent of adult patients.

November 20, —NCI scientists report that the incidence of oropharyngeal cancer significantly increased during the period among people in countries that are economically developed.

Recent studies from several countries have reported rising incidence of oropharyngeal cancers and subsequent studies have shown the human papilloma virus HPV as the potential cause.

Researchers note that prophylactic HPV vaccine has been shown to protect against oral HPV infection, suggesting an additional benefit of vaccination programs for both women and men.

March 1, —NCI transformed its longstanding Cooperative Group program into the new National Clinical Trials Network NCTN. Recent advances in deciphering the cancer genome have enabled the development of targeted therapies.

To explore targeted therapies, cancer clinical trials need to screen large numbers of patients with the same or different histologic tumor types to identify those patients whose tumors contain the distinct molecular targets of the therapies being tested.

March 5, — Ten winners of a world-wide competition to bring emerging breast cancer research technologies to market faster were announced today by the Avon Foundation for Women, in partnership with the NCI, and the Center for Advancing Innovation CAI.

ALCHEMIST represents three integrated, precision medicine trials that are designed to identify people with early-stage lung cancer who have tumors that harbor EGFR and ALK gene alterations and evaluate whether drug treatments targeted against those molecular changes can lead to improved survival compared to current standard of care therapy alone e.

August 30, —In a large international collaborative analysis of risk factors for non-Hodgkin lymphoma NHL , NCI scientists were able to quantify risk associated with medical history, lifestyle factors, family history of blood or lymph-borne cancers, and occupation for 11 different NHL subtypes, including less common subtypes.

These findings provide crucial insight into the diverse factors that drive different NHL subtypes and correspond with their biological and clinical characteristics. October 7, —President Obama announced that John Schiller, Ph.

The honorees received their medals at a White House ceremony later in as recognition for their outstanding contributions to discoveries that enabled the development of HPV vaccines. NCORP is a national network of investigators, cancer care providers, academic institutions, and other organizations.

NCORP replaced NCI's previously supported community networks: Community Clinical Oncology Program and the NCI Community Cancer Centers Program. NCORP conducts multi-site cancer clinical trials and studies in diverse populations in community-based healthcare systems across the United States and Puerto Rico with a goal of NCORP bringing cancer clinical trials and cancer care delivery research to individuals in their own communities.

Researchers at NCI intend to use this approach to find new, more effective treatments for various kinds of cancer based on increased knowledge of the genetics and biology of the disease and scientists hope to apply precision medicine to all areas of health and healthcare.

January 27, —In the largest prospective study to date of image-guided technology for identifying suspicious regions of the prostate to biopsy, NCI researchers compared the ability of this technology to detect high-risk prostate cancer with that of the current standard of unguided prostate biopsy.

April 20, —A new NCI study shows that inherited variations in a known tumor suppressor gene among children and adolescents with osteosarcoma, a cancer of the bone, are more common than previously thought. Older patients who are also susceptible to this malignancy were not found to carry mutations in the gene, known as TP June 1, —Investigators for the nationwide trial, NCI-MATCH Molecular Analysis for Therapy Choice , announced that the precision medicine trial will open to patient enrollment.

The study was co-developed by NCI and the ECOG-ACRIN Cancer Research Group, a cooperative group that was formed by the merger of the Eastern Cooperative Oncology Group ECOG and the American College of Radiology Imaging Network ACRIN. August 13, —Using novel large-scale imaging technology, NCI intramural researchers announced they have mapped the spatial location of individual genes in the nucleus of human cells and identified 50 cellular factors required for the proper three-dimensional 3D positioning of genes.

These spatial locations play important roles in gene expression, DNA repair, genome stability, and other cellular activities. The goal is to double the rate of progress against cancer, achieving in five years what otherwise would have taken ten. May 16, —NCI scientists found that leisure-time physical activity was associated with lower risks of 13 cancer types esophageal adenocarcinoma, liver, lung, kidney, gastric cardia, endometrial, myeloid leukemia, myeloma, colon, head and neck, rectal, bladder, and breast.

Most of these associations were evident regardless of body mass index or smoking history. These findings confirm and extend the evidence for a benefit of physical activity on cancer risk and support its role as a key component of population-wide cancer prevention. This data sharing platform promotes precision medicine in oncology.

It is an expandable knowledge network supporting the import and standardization of genomic and clinical data from cancer research programs. The GDC contains NCI-generated data from some of the largest and most comprehensive cancer genomic datasets, including The Cancer Genome Atlas TCGA and Therapeutically Applicable Research to Generate Effective Therapies TARGET.

As more researchers add clinical and genomic data to the GDC, it will become an even more powerful tool for making discoveries about the molecular basis of cancer that may lead to better care for patients. September 7, —NCI Acting Director Douglas Lowy, M.

December 7, — In a study of an immune therapy for colorectal cancer that involved a single patient, researchers identified a method for targeting the cancer-causing protein produced by a mutant form of the KRAS gene.

December 28, —In an early-phase intramural clinical trial of a new oral drug, selumetinib, children with the common genetic disorder neurofibromatosis type 1 NF1 and plexiform neurofibromas, tumors of the peripheral nerves, tolerated selumetinib and, in most cases, responded to it with tumor shrinkage.

At present, no therapies are considered effective for NF1-related large plexiform neurofibromas, but, in this trial, partial responses, meaning 20 percent or more reduction in tumor volume, were observed in over 70 percent of the patients.

NF1 affects 1 in 3, people. February 4, —Senator M. Neely, West Virginia, introduced Senate Bill to authorize a reward for the discovery of a successful cure for cancer.

March 7, —Senator M. Neely introduced Senate Bill to authorize the National Academy of Sciences to investigate the means and methods for affording Federal aid in discovering a cure for cancer and for other purposes. April 23, —Senator W. Harris, Georgia, introduced Senate Bill to authorize the Public Health Service and the National Academy of Sciences jointly to investigate the means and methods for affording Federal aid in discovering a cure for cancer and for other purposes.

April 2, —Senator Homer T. April 29, —Congressman Maury Maverick, Texas, introduced House Resolution to promote research in the cause, prevention, and methods of diagnosis and treatment of cancer, to provide better facilities for the diagnosis and treatment of cancer, to establish a National Cancer Center in the Public Health Service, and for other purposes.

The bill also calls upon NCI to assist and promote similar research at other public and private institutions. March 28, —House Joint Resolution , 75th Congress, was passed, "To dedicate the month of April in each year to a voluntary national program for the control of cancer.

July 1, —The Public Health Service Act, P. December 23, —The National Cancer Act of provides increased authorities and responsibilities for the NCI Director; initiating a National Cancer Program; establishing a 3-member President's Cancer Panel and a member National Cancer Advisory Board, the latter replacing the National Advisory Cancer Council; authorizing the establishment of 15 new research, training, and demonstration cancer centers; establishing cancer control programs as necessary for cooperation with state and other health agencies in the diagnosis, prevention, and treatment of cancer; and providing for the collection, analysis, and dissemination of all data useful in the diagnosis, prevention, and treatment of cancer, including the establishment of an international cancer data research bank.

November 9, —The Community Mental Health Centers Act amends the National Cancer Act to emphasize education and demonstration programs in cancer treatment and prevention, and stipulates that NCI devote more resources to prevention, focusing particularly on environmental, dietary and occupational cancer causes.

November 4, —The Health Research Extension Act of provides a two-year extension, which reaffirms the special authorities of NCI and added information dissemination mandates. A representative from the Department of Energy was added to the National Cancer Advisory Board as an ex officio member.

June 10, —The NIH Revitalization Act of encourages NCI to expand and intensify its efforts in breast cancer and other women's cancers and authorized increased appropriations. Similar language is included for prostate cancer.

Department of Defense breast cancer research. PL July 10, —The Radiation Exposure Compensation Amendments of allow more workers who handled radioactive material for weapons programs to be eligible to receive federal compensation for radiation-induced illness.

July 28, —The Semipostal Authorization Act gives the U. Postal Service the authority to issue semipostal stamps, which are sold at a premium in order to help provide funding for a particular area of research. The law also extends the Breast Cancer Stamp Act until July 29, January 4, —The Best Pharmaceuticals for Children Act is designed to improve the safety and efficacy of pharmaceuticals for children, by reauthorizing legislation that encourages pediatric drug research by giving drug companies an incentive of six months of additional market exclusivity to test their products for use in children.

May 14, —The Hematologic Cancer Research Investment and Education Act of directs the NIH Director, through the NCI Director, to conduct and support research on blood cancers.

In addition, the CDC is directed to establish and carry out an information and education program. September 10, —The Public Health Security and Bioterrorism Preparedness and Response Act contains a provision instructing Federal agencies to stockpile and distribute potassium iodide KI to protect the public from thyroid cancer in the event of a radiation emergency.

June 30, —The Patient Navigator Outreach and Chronic Disease Prevention Act of amends the Public Health Service Act to authorize a demonstration grant program to provide patient navigator services to reduce barriers and improve health care outcomes.

The bill directs the HHS Secretary to require each recipient of a grant under this section to use the grant to recruit, assign, train, and employ patient navigators who have direct knowledge of the communities they serve to facilitate the care of individuals who have cancer or other chronic diseases.

The bill also directs the HHS Secretary to coordinate with, and ensure the participation of, the Indian Health Service, NCI, the Office of Rural Health Policy, and such other offices and agencies as deemed appropriate by the Secretary, regarding the design and evaluation of the demonstration programs.

November 11, —The 2-Year Extension of Postage Stamp for Breast Cancer Research extends the U. Postal Service's authority to issue special postage stamps to help provide funding for breast cancer research through December 31, January 12, —The Gynecologic Cancer Education and Awareness Act of , or "Johanna's Law" directs the HHS Secretary to carry out a national campaign to increase the awareness and knowledge of health care providers and women with respect to gynecologic cancers.

April 20, —The National Breast and Cervical Cancer Early Detection Program Reauthorization Act of allows states to apply for federal waivers to spend a greater share of funds on hard-to-reach underserved women.

September 27, —The FDA Amendments Act of amends the Federal Food, Drug, and Cosmetic Act to reauthorize the collection of prescription drug user fees for FY—FY Requires NIH to expand the clinical trial registry clinicaltrials. gov and creates a clinical trial results database. December 12, —The Breast Cancer Research Stamp Reauthorization Act extends through December 31, , provisions requiring the U.

Postal Service to issue a special postage stamp which contributes to funding breast cancer research. July 29, —The Caroline Pryce Walker Childhood Cancer Act of amends the Public Health Service Act to advance medical research and treatments into pediatric cancers, ensure patients and families have access to the current treatments and information regarding pediatric cancers, establish a population-based national childhood cancer database, and promote public awareness of pediatric cancers.

October 8, —The Breast Cancer and Environmental Research Act of amends the Public Health Service Act to authorize the Director of the National Institute of Environmental Health Sciences to make grants for the development and operation of research centers regarding environmental factors that may be related to the etiology of breast cancer.

The bill establishes an Interagency Breast Cancer and Environmental Research Coordinating Committee within HHS. June 21, —The Family Smoking Prevention and Tobacco Control Act provides the FDA with the authority to regulate tobacco products and establishes within the FDA, the Center for Tobacco Products to implement this act.

The Act allows the Secretary of HHS to restrict the sale or distribution and the advertising or promotion of tobacco products, if appropriate for the protection of the public health, and to the full extent permitted by the First Amendment. March 23, —The Patient Protection and Affordable Care Act HR , the health care reform bill, establishes a private non-profit institute called the Patient-Centered Outcomes Research Institute to conduct comparative clinical effectiveness research, obtain and use data from the Federal government, and establish advisory panels to advise on research priorities, among other provisions.

The bill requires NIH to conduct research to develop and validate new screening tests for breast cancer. The bill also requires the NIH Director to establish a Cures Acceleration Network CAN program, which shall award grants and contracts to eligible entities to accelerate the development of high need cures and therapies, including the development of medical products, drugs or devices, or biological products.

March 31, —The Prevent All Cigarette Trafficking Act of prevents tobacco smuggling, ensures the collection of all tobacco taxes, and includes smokeless tobacco as a regulated substance. The bill amends the federal criminal code to treat cigarettes and smokeless tobacco as non-mailable and prohibit such items from being deposited in or carried through the U.

December 23, —The Breast Cancer Research Stamp Reauthorization Act reauthorized provisions requiring the U. Postal Service to issue a special postage stamp which contributes to funding breast cancer research, extending them through January 2, —The Recalcitrant Cancer Research Act of passed as an amendment to the National Defense Authorization Act for Fiscal Year The legislation calls for NCI to develop a scientific framework for research on two cancers that have a five-year relative survival rate of less than 20 percent, and are estimated to cause the death of at least 30, individuals in the United States per year.

Pancreatic cancer and lung cancer meet these criteria. December 11, ­ —The Breast Cancer Stamp Reauthorization Act reauthorized the issuance of semipostal stamps for breast cancer research, through December 13, — The 21 st Century Cures Act increases funding for biomedical research, and aims to enhance the speed at which drugs are developed and approved.

Key NIH provisions aim to coordinate policies relating to early career investigators, improve loan repayment programs, and streamline procedural requirements for attendance at scientific meetings. The funds in the Account must be appropriated annually. Kimryn Rathmell, M.

She previously led the Vanderbilt University Medical Center as physician-in-chief and chair of the Department of Medicine. Rathmell is a recipient of the Louisa Nelson Award for Women of Achievement, Vision, and Inspiration , the Eugene P. Schonfeld Award from the Kidney Cancer Association , and the Paragon Award for Research Excellence from the Doris Duke Foundation.

She has served on the NCI Board of Scientific Advisors , and the Forbeck Foundation Scientific Advisory Board. Rathmell has held leadership positions with the American Society of Clinical Oncology and the American Society for Clinical Investigation, serving as secretary—treasurer and president.

As a result of her efforts, Dr. Rathmell has been elected to the Association of American Physicians, the American Academy of Arts and Sciences, and the National Academy of Medicine.

Rathmell earned undergraduate degrees in biology and chemistry from the University of Northern Iowa and her Ph. in biophysics and M. from Stanford University. She completed an internal medicine internship at the University of Chicago and an internal medicine residency, medical oncology fellowship, and postdoctoral studies at the University of Pennsylvania.

In , she completed her Master of Management in Health Care from the Vanderbilt University Owen Graduate School of Management.

The National Cancer Institute leads the National Cancer Program through its operation of research components that provide support for extramural and intramural cancer-related research and through its outreach and collaborations within the cancer community worldwide.

Cancer research is conducted with NCI funding in nearly every state in the United States and more than 20 foreign countries, in addition to research conducted at its own facilities. NCI supports cancer research training, education, and career development, and provides leadership for setting national priorities in cancer research.

The CCR is the largest division of the NCI intramural research program and comprises over basic and clinical research groups located on two campuses outside of Washington, D. Our scientists work on a wide spectrum of biological and biomedical problems ranging from visualizing and understanding the structure of individual genes and proteins, developing novel methods for drug discovery, to inventing biomedical devices and technology and creating innovative ways to treat patients in the NIH Clinical Center.

Our scientists enjoy complete intellectual freedom and are expected to creatively and innovatively explore the most important questions in the field of cancer research and treatment.

We support projects over a long time horizon allowing our investigators to pursue some of the most difficult, high-risk problems in the field and we are always on the lookout for new challenges and the most pressing problems in modern cancer research. The success of the CCR is grounded in an exceptionally strong discovery research program which provides the foundation for the seamless translation of insights into basic cellular and molecular processes to clinical applications and patient care.

The CCR is a unique place of science where we combine diverse expertise with the freedom to thoroughly pursue the most pressing questions in cancer biology and treatment.

Through its broad programs in epidemiology, genetics, statistics, and related areas, the intramural Division of Cancer Epidemiology and Genetics DCEG carries out population-based and interdisciplinary research both nationally and internationally to discover the genetic and environmental determinants of cancer.

DCEG is uniquely positioned to conduct value-added epidemiologic research projects that are high-risk in nature and require a long-term commitments of scientific staff and funding support through contracts, b a coordinated national programmatic approach, or c a rapid response to emerging public health or scientific issues.

The Division develops multi-disciplinary infrastructures and resources for use throughout the scientific community, including database management software for genome-wide association studies, biospecimen inventories, family-based studies, a variety of software packages for exposure assessment, and interactive cancer mortality atlases to generate leads into the environmental determinants of cancer.

DCEG also has a firm commitment to training the next generation of scientists, and has trainees from the predoctoral to postdoctoral stage.

The research conducted by the Division often provides a scientific basis for public health recommendations and policies. The Epidemiology and Biostatistics Program consists of five branches that conduct independent and collaborative epidemiologic and biostatistical investigations to identify the distribution, characteristics, and causes of cancer in human populations.

The Program investigates demographic variation in the occurrence of cancer by age, race, gender, geography, and over time.

Special emphasis is placed on the carcinogenic effects of occupational and environmental exposures, ionizing and non-ionizing radiation, dietary and metabolic factors, medicinal agents such as hormones, infectious agents, and host factors including genetic susceptibility to cancer-causing exposures.

The Program also develops biostatistical methods for family-based and population-based studies on cancer etiology and prevention. The Human Genetics Program provides an expanded focus for interdisciplinary research into the genetic determinants of human cancer.

Its branches and laboratory explore and identify heritable factors that predispose to cancer, including studies of gene-environment interactions.

Program investigators study cancer-prone families to identify and clone predisposing genes; investigate the prevalence of identified genes in the general population; conduct pharmacogenetic studies to evaluate genetic polymorphisms as determinants of cancer risk and treatment outcomes; conduct integrative analyses of environmental and germline risk factors with comprehensive data on histological and molecular profiling of tumors and their precursors, including somatic genomic analyses; and translate advances in molecular genetics into evidence-based management strategies.

The Laboratory of Translational Genomics examines validated regions of the genome associated with cancer risk, laying the groundwork for functional studies to determine the causal variants and biological mechanisms involved. These activities are complemented by the NCI Cancer Genomics Research Laboratory, where genome-wide association studies and next generation sequencing are carried out to uncover the heritable components to cancer.

Fellows in the DCEG Fellowship Program work with world class scientists to explore the causes of cancer and new approaches to its prevention. Predoctoral and postdoctoral fellows carry out, analyze, and publish population, family, and laboratory-based studies.

They gain experience in diverse study designs, novel analytic techniques, and genomics and informatics. Professional skills development and preparation for future careers in epidemiology and related areas are an integral part of the program.

The Division of Cancer Biology DCB supports basic research in all areas of cancer biology and provides the research foundation that improves understanding of the disease. This basic research may lead to new approaches for prevention, diagnosis, and treatment.

Research on basic cancer biology provides the building blocks to new treatments and clinical trials. DCB provides scientific management for approximately 2, grants each year.

DCB facilitates investigator-initiated research by working with individual investigators, professional societies, and research institutions to provide information, advice, and guidance on opportunities for research support. At the forefront of cancer research, DCB establishes program priorities by identifying and addressing emerging scientific areas or gaps in the scientific research portfolio and reports on scientific progress and program accomplishments to the scientific community, NCI, Congress, and the public.

Basic research is supported by the Division in the following major research areas: cancer cell biology; cancer immunology, hematology, and etiology; DNA and chromosome aberrations; structural biology and molecular applications; tumor biology and microenvironment; and tumor metastasis.

Special research programs within DCB include: Physical Sciences-Oncology Network, Cancer Systems Biology Consortium, Oncology Models Forum, Barrett's Esophagus Translational Research Network, New Approaches to Synthetic Lethality for Mutant KRAS-Dependent Cancers, Molecular and Cellular Characterization of Screen-Detected Lesions, Fusion Oncoproteins in Childhood Cancers, and Cancer Tissue Engineering Collaborative.

DCCPS, an extramural division, supports research in surveillance, epidemiology, health services, behavioral science, and cancer survivorship. The division also plays a central role within the federal government as a source of expertise and evidence on issues such as the quality of cancer care, the economic burden of cancer, geographic information systems, statistical methods, communication science, comparative effectiveness research, obesity and tobacco control, and the translation of research into practice.

In addition to an emphasis on epidemiology and biostatistics, DCCPS has made a special effort to recruit experts in disciplines such as communication, anthropology, outcomes research, psychometrics, medical genetics, health psychology, economics, social work, policy analysis, geography, and family medicine.

The Office of Cancer Survivorship is housed within DCCPS and promotes a better understanding of the unique needs of cancer survivors and how to address those needs. The Division of Cancer Prevention DCP conducts and supports research to determine a person's risk of developing cancer and to find ways to reduce that risk.

Through laboratory, clinical, and epidemiologic research, scientists have shown that the diseases of cancer occur not as single, catastrophic events, but rather as the result of a complex and long-evolving molecular process.

The intervals between initiation of the cancer process and occurrence of the invasive disease vary by organ and tissue sites, and some may take decades. DCP research portfolio focuses across this span, with a goal to detect changes and intervene early in the cancer process to prevent disease and death.

Research groups include: Chemopreventive Agent Development Research Group, Community Oncology and Prevention Trials Research Group, Nutritional Science Research Group, Cancer Biomarkers Research Group, Early Detection Research Group, Biometry Research Group, and four organ system research groups.

The Division of Cancer Treatment and Diagnosis DCTD takes prospective detection and treatment leads, facilitates their paths to clinical application, and expedites the initial and subsequent large-scale testing of new agents, biomarkers, imaging tests, and other therapeutic interventions radiation, surgery, immunotherapy in patients.

Investigators supported by the division engage in scientifically sound, high-risk research that may yield great benefits for patients with cancer, but are too difficult or risky for industry or academia to pursue. This includes a particular emphasis on the development of distinct molecular signatures for cancer, refined molecular assays, and state-of-the-art imaging techniques that will guide oncologic therapy in the future as well as a commitment to precision medicine initiatives.

The division has eight major programs that work together to bring unique molecules, diagnostic tests, and therapeutic interventions from the laboratory bench to the patient bedside: The Biometric Research Program, The Cancer Diagnosis Program, The Cancer Imaging Program, The Cancer Therapy Evaluation Program, The Developmental Therapeutics Program, The Radiation Research Program, The Translational Research Program, and The Office of Cancer Complementary and Alternative Medicine.

The Division of Extramural Activities DEA was established to provide NCI and the scientific community with expert scientific review of the merits of extramural research, procedures, and policies to help the Institute achieve its goal.

DEA coordinates NCI's extramural initiatives by guiding funding, providing scientific peer review and oversight, coordinating advisory committees, establishing policies and procedures, managing extramural staff training and career development, and coding and tracking NCI's research portfolio.

DEA staff members serve as chief NCI liaisons to the extramural cancer research community, processing approximately 12, grant applications for referral and recruiting thousands of scientific experts to review approximately 3, grants per year.

The DEA's Committee Management Office handles the complex preparation and logistics required for NCI's advisory groups to function productively and for the HHS Secretary's Advisory Committee on Genetics, Health, and Society to act in its prescribed role.

NCI established the Center for Cancer Genomics CCG in to develop and apply genome science to improve the diagnosis and treatment of cancer patients. CCG promotes collaborations of national and international agencies, academic researchers, and community physicians to foster research based on genomes, gene expression, proteomics, and other technologies to usher in a modern era of integrated and individualized prevention, diagnosis, and treatment of cancer, while ensuring responsible use of genetic information.

Through research on the structure and function of the molecular make-up of human tumor cells and the human genome, researchers funded by CCG have identified many genes involved in cancer that are informing knowledge of biologic function, drug development, and DNA-based diagnostics.

CCG and the offices it oversees—The Cancer Genome Atlas TCGA and the Office of Cancer Genomics OCG —manage multiple programs. These offices serve to advance CCG's goal of ushering in a modern era of diagnosis, treatment, and prevention based on the study of genomes.

Programs include: Genomic Data Commons, Cancer Driver Discovery Program, Cancer Genome Characterization Initiative, Cancer Target Discovery and Development Network, Human Cancer Models Initiative, and Therapeutically Applicable Research to Generate Effective Treatments.

The Center for Cancer Training CCT is committed to catalyzing the development of a 21st century workforce capable of advancing cancer research through a scientifically integrated approach. CCT coordinates and provides research training and career development activities for NCI's laboratories, clinics, and other research groups.

These cancer training and career development opportunities cover a broad spectrum of disciplines for individuals at career stages ranging from high school and graduate students to scientists, clinicians, and health care professionals.

CCT is responsible for developing, coordinating, and implementing opportunities for support of cancer research training, career development, and education at institutions nationwide. CCT identifies workforce needs in cancer research and adapts NCI's training and career development programs and funding opportunities to address these needs.

CCT creates new opportunities that enhance recruiting and retention, increase partnerships, and generate diversity awareness.

The Center for Global Health CGH was established in to help reduce the global burden of cancer. CGH develops initiatives and collaborates with other NCI divisions, NCI-designated cancer centers, and countries to support cancer control planning build capacity, and support cancer research and cancer research networks in low- and middle-income countries.

CGH serves as the focal point for all global health activities within NCI by leading the development of global cancer research priorities, providing strategic vision to the global cancer community, and pursuing strategies directed towards control of cancer on a global scale.

CGH conducts and supports international cancer research, training, health information dissemination, and other relevant biomedical research programs.

It coordinates collaborations and partnerships with other agencies and organizations engaged in efforts to improve global health. Research programs and initiatives include: Cancer Control Planning, Capacity Building, and Cancer Research and Research Networks.

The Center for Strategic Scientific Initiatives CSSI focuses on creating and uniquely implementing exploratory programs focused on the development and integration of advanced technologies, trans-disciplinary approaches, infrastructures, and standards to accelerate the creation of publicly available, broadly accessible, multi-dimensional data, knowledge, and tools to empower the entire cancer research continuum for patient benefits.

Since its inception, CSSI has undertaken a number of programs and initiatives that have contributed significantly to addressing major barriers and opportunities in cancer research. These initiatives are also designed to enable advances that can be translated to the clinic and substantially impact patient care.

CSSI programs build databases, knowledge, tools and extramural trans-disciplinary scientific teams to promote the themes of the center. Offices include: CSSI Office of the Director, Office of Cancer Clinical Proteomics Research , and Office of Cancer Nanotechnology Research.

The National Outreach Network NON seeks to strengthen NCI's ability to develop and disseminate culturally appropriate, evidence-based cancer information that is tailored to the specific needs and expectations of underserved communities, working through NON community health educators located at NCI-designated Cancer Centers.

CRCHD supports the following research programs: Community Networks Program Centers, Partnerships to Advance Cancer Health Equity, Basic Cancer Research Program, Continuing Umbrella of Research Experiences, and Geographical Management of Cancer Health Disparities Program.

The AIDS Malignancy Program identifies new initiatives for international activities, such as the initiative to Strengthen Capacity for HIV-Associated Malignancy Research in Africa , and oversees programs that NCI co-manages with other Institutes. The AIDS Cancer Clinical Program oversees clinical programs in OHAM, including the AIDS Malignancy Consortium and the AIDS and Cancer Specimen Resource.

Small Business Innovation Research SBIR and Small Business Technology Transfer STTR programs at NCI are managed by the SBIR Development Center.

These programs are NCI's engine of innovation for developing and commercializing novel technologies and products to prevent, diagnose, and treat cancer. A range of funding opportunities is offered to the small business community. The center offers advice for applicants and fosters partnerships and collaborations between small businesses and third-party organizations.

In addition, the center serves as a mentor to SBIR-funded companies regarding their technology development plans, and their regulatory and commercialization strategies, helping to accelerate the development of novel technologies and products.

The primary goal of these efforts is to enhance the return on investment of the SBIR program for the benefit of the cancer community and public health in general. SBIR and STTR serve as two of the largest sources of early-stage technology financing in the United States.

The Office of Cancer Centers OCC program supports 72 NCI-designated Cancer Centers nationwide that are actively engaged in transdisciplinary research to reduce cancer incidence, morbidity, and mortality. These NCI-designated Cancer Centers are a major source of discovery of the nature of cancer and the development of more effective approaches to cancer prevention, diagnosis, and therapy.

They also deliver medical advances to patients and their families, educate health-care professionals and the public, and reach out to underserved populations. They are characterized by strong organizational capabilities, institutional commitment, and trans-disciplinary, cancer-focused science; experienced scientific and administrative leadership, and state-of-the-art cancer research and patient care facilities.

NCI-designated Cancer Centers are funded through the P30 Cancer Center Support Grant. Cancer affects all of us — either directly or through a loved one. These stories are the foundation to the mission of the Moonshot, and in pursuit of ending the scourge of cancer we sought out these stories to ensure our efforts are grounded in the patient journey.

Read the stories of how everyday people are making a difference on the Cancer Moonshot publication , or find out how you can volunteer in your community. Today, cancer is a leading cause of death worldwide. Taking on cancer is personal for the Vice President — and for nearly every American and millions of people around the world who personally, or through a family or friend, are affected by it.

If this is personal for you — if your life or the life of someone you know has been touched by cancer, share your story with the Vice President here. You just might hear from him. Tell your story.

If you simply are looking for a way to help , check out cancer. gov to find volunteer opportunities in your community. On January 12, , President Obama tasks Vice President Biden with leading a "Moonshot" to help end cancer as we know it. Over 7, more came together at hospitals, community care centers, businesses, and in family rooms at more than local summits across all 50 states, Puerto Rico, Guam, and Washington, D.

This marked the first time that individuals and organizations spanning the entire cancer community and beyond convened under the national charge of doubling the rate of progress toward a cure and making a decade worth of advances in cancer prevention, diagnosis, and treatment in five years.

Skip to Content Skip to Navigation. Cancer Moonshot. Close Achieving lift off Since the launch of the White House Cancer Moonshot, Vice President Biden, the Cancer Moonshot Task Force, and the Blue Ribbon Panel of experts have engaged thousands of cancer patients and their caregivers, clinicians, health organizations, advocacy groups, researchers, technologists, industry leaders, and more across America in support of achieving our bold mission.

Read the Vice President's Executive Report Read the Task Force Report. Close The Cancer Moonshot is a mission, and all of us CanServe.

Biden-Harris Jnitiatives Sets Goal of Reducing Initiativees Death Rate Nutritional support for athletes at least 50 Sports training adaptations Over Magnesium for depression Next 25 Anti-cancer initiatives, injtiatives Improving the Experience Anti-canxer Living with Anti-cancer initiatives Surviving Cancer. Anti-cance Vice President, in Anti--cancer, Joe Anti-cancerr launched the Cancer Moonshot with the mission to accelerate the rate of progress against cancer. The cancer and patient community and medical researchers responded with tremendous energy and ingenuity. Today, President Biden is reigniting the Cancer Moonshot with renewed White House leadership of this effort. The President and First Lady Jill Biden are also announcing a call to action on cancer screening to jumpstart progress on screenings that were missed as a result of the pandemic, and help ensure that everyone in the United States equitably benefits from the tools we have to prevent, detect, and diagnose cancer. More ». Initiafives Anti-cancer initiatives Cancer Institute Initiatiges is the federal government's initiativds agency for cancer research and training. Established under the National Cancer Institute Act Anti-cancer initiativesMagnesium for depression initiqtives Anti-cancer initiatives of Natural fat burning capsules National Institutes Anti-canccer Health NIHone of 11 agencies that make up the Department of Health and Human Services HHS. Specifically, NCI focuses on two broad roles:. As a federal agency, NCI receives its funds from Congress. The bulk of our budget supports extramural grants and cooperative agreements to facilitate research conducted at universities, medical schools, hospitals, cancer centers, research laboratories, and private firms in the United States and abroad.


Frontier Science #20 - Cancer Vaccines \u0026 Translational Medicine w/ Nora Disis - Prof. @ UW - BIOS

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