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Herbal metabolism regulator

Herbal metabolism regulator

Sun B, Regulatod M, Kudo M, Wu L, Leafy green market L, Rdgulator M, et al. Leafy green market Google Scholar Liu B, Zhao C, Li H, Chen X, Ding Y, Xu S. Furthermore, the immunological landscape or metabolic landscape of human cancer and herbal ingredients were constructed. Between andnearly half of all U. Statistical analysis Significance between vehicle and LIPOSA was determined by paired Student's t-test.

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US security threat, Biden's health, DA Willis \u0026 Middle East ceasefire Everyone is looking for Herbla magical pill to regulxtor them lose fegulator. Even regulatoor no such Herabl Leafy green market, there Foods That Boost Metabolism several herbs Leafy green market can help improve your metabolism and help with weight loss. There are some herbs to boost metabolism and weight loss. They provide a thermogenic effect to increase your metabolism. Other herbs reduce hunger so you can naturally reduce your calorie consumption. As with any medication or herbal remedy, these herbal formulas must be properly used to maximize your weight loss efforts while minimizing unwanted side effects. When weight management herbs are used in conjunction with a diet and exercise program, weight loss is achievable.

Herbal metabolism regulator -

PDF Resources. Skill Videos. Page Navigation Herbs for Weight Loss Resistance Insulin Resistance Thyroid Hormone Sex Hormones Inflammation References. Receive clinically driven nutrition insights you can trust. Herbs for Weight Loss Resistance Finding a way to achieve and maintain a healthy weight in a sustainable way can improve multiple long-term health parameters, and weight loss is a journey with which many people are familiar.

Insulin Resistance Insulin is a hormone that sends a growth signal to the body, ultimately resulting in the storage of glucose; when insulin is secreted in excess, glucose will be stored as fat.

Thyroid Hormone Thyroid hormone plays a significant role in metabolism and can be targeted to overcome weight loss resistance. Sex Hormones Because sex hormones contribute to weight loss resistance, they are also a possible target for intervention, especially in women where estrogen and progesterone have significant effects.

Inflammation Finally, inflammation can be a major barrier to losing weight. References Kanetkar, P. Gymnema sylvestre: A Memoir. J Clin Biochem Nutr, 41 2 Ghorbani, A. Best herbs for managing diabetes: A review of clinical studies. Braz J Pharm Sci, 49 3 Ranasinghe, P. Diabetic Med , 29 12 Xu, X.

Therapeutic effect of berberine on metabolic diseases: Both pharmacological data and clinical evidence. Biomed Pharmacother, Majeed, M. Lesser Investigated Natural Ingredients for the Management of Obesity. Nutrients, Laurberg, P.

Forskolin stimulation of thyroid secretion of T 4 and T 3. FEBS Lett, 2 Loftus, H. Coleus forskohlii Extract Supplementation in Conjunction with a Hypocaloric Diet Reduces the Risk Factors of Metabolic Syndrome in Overweigh and Obese Subjects: A Randomized Controlled Trial.

Nutrients, 7 11 : Godard, M. Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men. Obes Res, 13 8 : Sharma, A. Efficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients: A Double-Blind Randomized Placebo-Controlled Trial.

J Altern Complement Med, 24 3 Chen, L. An Integrated Approach Exploring the Synergistic Mechanism of Herbal Pairs in a Botanical Dietary Supplement: A Case Study of a Liver Protection Health Food. Int J Genomics, Herbal mixture for weight loss and metabolism regulation - Green BSN.

Herbal mixture for weight loss and metabolism regulation 1. Herbal mixture for weight loss and metabolism regulation quantity.

Description Contents: 40 filter bags of 1. Instructions Put two filter bags. Net 60 g. Related products Sale. Studies have confirmed the beneficial effects of arginine and its metabolite agmatine on metabolic diseases, including the promotion of insulin secretion, improving insulin resistance, and increasing cellular glucose uptake Okazaki, et al.

Notably, some herbs have been found to regulate the metabolism of these amino acids in rodents with metabolic diseases. Sophora flavescens Ait. Leguminosae; Sophorae Flavescentis Radix significantly decreased the levels of fasted blood glucose, glycosylated serum protein, and glycosylated hemoglobin in T2DM rats by regulating gut bacteria and host-microbial metabolism, including increasing indole and tyramine levels Shao et al.

Similarly, the Naoxintong capsule improved hyperglycemia and hyperlipidemia in T2D rats, and its anti-diabetic mechanisms are related to the improvement of gut microbial disorders and regulation of tyrosine and tryptophan biosynthesis Yan et al.

Moreover, Shao et al. flavescens Ait. Leguminosae; Sophorae Flavescentis Radix had good anti-diabetes effects on T2DM rats and might upregulate arginine and proline metabolism by reducing the abundance of Prevotella , Roseburia , and Faecalibacterium. Branched-chain amino acids BCAAs , such as leucine, isoleucine, and valine, have been shown to be closely associated with metabolic disease.

Yu et al. In addition, Zhou et al. Some gut microbes, such as Streptococcus and Prevotella , are involved in BCAA biosynthesis and catabolism. One study found that berberine improved glycemic control and alleviated insulin resistance in HFD-fed mice, which was associated with altered gut microbiota in BCAA biosynthesis Yue et al.

Specifically, berberine treatment significantly reduced the relative abundance of BCAA-producing bacteria and serum BCAA levels. Meanwhile, berberine reduced the gut microbial genes involved in BCAA biosynthesis but enriched the genes involved in BCAA degradation and transport.

In addition, Gao et al. The results showed that the Qijian mixture significantly alleviated T2DM, and its anti-diabetic mechanisms were related to the regulation of gut microbiota and the reduction of several amino acids, including three BCAAs leucine, isoleucine, and valine.

Cholesterol is converted to BAs in the liver under the action of cholesterol 7α-hydroxylase CYP7A1 and CYP27A1. When BAs are secreted into the intestine, gut microbes can participate in their metabolism and maintain their homeostasis Wahlstrom et al.

For example, conjugated BAs, such as tauro-conjugated β-MCA T-β-MCA and glycoursodeoxycholic acid GUDCA , can be converted into secondary BAs under the action of the bile salt hydrolase BSH of some gut bacteria, including Clostridium , Bacteroides , Lactobacillus , and Bifidobacterium Jia et al.

BAs play an important role in glucose and lipid metabolism by acting on two receptors, namely, the farnesoid X receptor FXR and Takeda G protein-coupled receptor 5 TGR5.

Bile acid metabolism disorder has been shown to be closely related to the progression of metabolic diseases Cai et al. Several herbal medicines have been reported to regulate gut bacteria-related bile acid metabolism.

The Tianhuang formula showed a lipid-lowering effect through the gut microbiota—T-β-MCA—FXR axis Yang et al. Specifically, it regulated gut microbes and inhibited their BSH activities, which thereby increased T-β-MCA levels and further inhibited intestinal FXR, which lead to increased bile acid synthesis and reduced lipid levels.

Similarly, Lu et al. In addition, S. baicalensis Georgi Labiatae; Scutellariae Radix improved hyperglycemia and hyperlipidemia in T2DM rats by regulating the interaction between gut microbiota and bile acid metabolism Zhao et al. Specifically, the administration of S.

baicalensis Georgi Labiatae; Scutellariae Radix significantly improved gut microbiota dysregulation e. Similar to the liver, the gut plays an important role in the metabolism of oral drugs. After oral administration, herbal medicines contact and interact with gut microbes in the colon.

The gut microbiota harbors many types of enzymes, such as glycoside hydrolase, oxidase, reductase, and esterase, which can metabolize and transform the chemical components of herbal medicines. These biotransformations may enable herbs to have better bioavailability and bioactivity or less toxicity Feng et al.

Next, we categorically describe the different mechanisms by which gut microbes influence the metabolism and efficacy of some herbal medicines. Phytochemicals in herbal medicines are generally low in bioavailability, but some metabolites that are transformed by the gut microbiota may exhibit better bioavailability than their precursors.

Ellagitannins, for example, are a group of polyphenols found in pomegranates and Phyllanthus emblica L. Euphorbiaceae; Phyllanthi Fructus that have low bioavailability. However, their gut microbial metabolites, urolithins urolithin A, B, C, and D , are more readily absorbed and have better bioavailability than ellagitannins Espin et al.

Interestingly, urolithins e. Thus, the therapeutic effect of pomegranates and P. emblica L. Euphorbiaceae; P. fructus on metabolic diseases may be attributed to urolithins produced by the gut microbiota rather than the polyphenols they contain.

In addition, some metabolites produced by gut microbiota may have better bioactivity than their precursors. For instance, protopanaxadiol-type ginsenosides, including ginsenoside Rb1 in Panax ginseng , can be metabolized by the gut microbiota into compound K.

There is increasing evidence that compound K has a good anti-diabetic effect Jiang et al. In particular, several studies have shown that compound K has better antidiabetic, anti-inflammatory, and hepatoprotective activities than protopanaxadiol-type ginsenosides or ginsenoside Rb1 Lee et al.

These findings help elucidate the key role of gut microbes in herbal treatments for metabolic diseases.

The toxicity or side effects of herbal medicines have aroused wide concern. The gut microbiota can convert some herbal compounds into less toxic metabolites. Aconitine is a well-known toxic ingredient found in Aconitum medicinal plants. Aconitine can be metabolized to benzoylaconine and lipoaconitine by human gut bacteria through deacetylation, demethylation, and esterification reactions.

and thus reduce its toxicity Kawata et al. Baicalin is the main active ingredient of S. baicalensis Georgi Labiatae; Scutellariae Radix.

Studies have shown that baicalin can be converted into baicalein by the gut microbiota, and baicalein has less toxicity on HepG2 cells than baicalin Khana et al.

Notably, baicalein has hepatoprotective, anti-dyslipidemia, anti-obesity, anti-inflammatory, and anti-diabetic activities Fang et al. In addition to these direct transforming effects, some metabolites derived from gut bacteria also help reduce the toxicity of herbal medicines.

Triptolide, which is a natural compound isolated from Tripterygium wilfordii Hook F Celastraceae; Triptergii Radix et Rhizoma , has good anti-inflammatory and neuroprotective activities Li et al.

It also ameliorates hepatic lipogenesis, inflammation, and fibrosis in NAFLD Huang et al. However, its clinical application is limited due to its severe hepatotoxicity. Recently, a study found that gut microbiota-derived propionate could ameliorate triptolide-induced hepatotoxicity Huang et al.

Specifically, propionate supplementation significantly reduces plasma transaminase, improves liver histology, and decreases liver and plasma malondialdehyde MDA levels. As described above, the therapeutic effects of herbal medicines on metabolic diseases are closely related to their interaction with the gut microbiota.

With the development of science and technology, multidisciplinary techniques and methods can be used to study the complex relationship between herbs, gut microbiota, and diseases.

Next, we summarize and discuss some techniques and methods for studying the bidirectional interactions between herbal medicines and gut microbiota Figure 4.

FIGURE 4. Methodology for studying the bidirectional interaction between herbal medicines and the gut microbiota. HM, herbal medicine. To determine the therapeutic effect of herbal medicines on metabolic diseases and the key role of the gut microbiota, four experimental groups were created: a control group, a model group, a herbal medicine group, and an herbal medicine plus antibiotic group.

After the experiment, common biochemical indicators, gut microbiota, and microbial metabolites in each group were detected and analyzed. The 16S rRNA technique can be used to detect bacteria in samples based on polymerase chain reaction PCR amplification.

The main challenges in using this technique are the lack of a standardized workflow and the difficulty in identifying bacteria at the species level. Metagenomics is a widely used technique that can identify microorganisms at the species and even strain level Jovel et al. In addition, it can also perform a functional analysis of microbial communities.

However, methodological biases and inter-individual differences must be considered during data interpretation. Recently, advanced techniques have been developed to study the composition and function of gut microbes. For example, metatranscriptomics can provide knowledge of the transcriptional profiles of microbial populations, which is beneficial in revealing the molecular activities of gut microbes and their regulatory mechanisms Zhang et al.

Similarly, metaproteomics is a powerful tool that can be used to study the functional activity of gut microbes by characterizing the complex composition of microbial proteins Stamboulian et al.

Enzyme-linked immunosorbent assay ELISA , real-time fluorescent quantitative PCR, Western blot, and immunohistochemistry methods can be used to detect biochemical markers related to metabolic diseases e.

Metabolomics can be used to determine changes in microbial metabolites after drug administration van Treuren and Dodd, For example, GC-MS technology can accurately measure the levels of SCFAs produced by gut microbial fermentation, while HPLC-QqQ-MS technology can accurately determine the concentration of BAs.

These MSI techniques help us understand the effects of herbal medicines on gut microbial metabolites in two or three dimensions. Additionally, bioinformatic methods can be used to study the correlation between the pharmacodynamic effects of herbal medicines and changes in gut microbes and their metabolites.

In addition to antibiotic interventions, fecal microbiota transplantation FMT can also be used to identify the critical role of the gut microbiota in the herbal treatment of metabolic diseases. After oral administration, herbal ingredients can be metabolized by gut microbes, and their metabolites are then absorbed into the circulation, producing pharmacological activity van Duynhoven et al.

To determine whether the gut microbiota is involved in the metabolism of herbal ingredients, three experimental groups were created: a control group, a herbal medicine intervention group, and a herbal medicine intervention plus antibiotic group.

After the experiment, animal biological samples, including feces or intestinal contents and serum, need to be collected. Feces or intestinal contents can be used to determine herbal metabolites after gut microbial transformation, while serum can be used to determine the absorption of these metabolites and whether bioavailability is improved.

Due to the low levels of these metabolites in biological samples, high-sensitivity analytical instruments are needed for their detection. Ultra-high-performance liquid chromatography coupled with Orbitrap mass spectrometry UPLC-Orbitrap-MS and HPLC-QqQ-MS have been shown to accurately detect and identify metabolites of herbal phytochemicals in rat intestinal contents and serum samples Du et al.

Furthermore, additional experimental validation is needed to determine whether the metabolites after gut microbial transformation have a better biological activity or lower toxicity than their precursors.

In short, medium-pressure preparation liquid chromatography and high-speed countercurrent chromatography can be used for the targeted separation of specific metabolites.

Then, cellular or animal experiments can be performed to compare the activity or toxicity of these metabolites with their precursors. Gut microbes and their metabolites have recently been implicated to be involved in the pathogenesis of metabolic diseases Fan and Pederson, ; Du et al. Consequently, the gut microbiota may be a potential target for herbal treatments of metabolic diseases.

Several articles have summarized the association between gut microbiota and herbal medicines Xu et al. However, the critical role of gut microbiota in the herbal treatment of metabolic diseases has not been fully described. Therefore, this review provides a comprehensive and up-to-date summary of the relationship between herbal medicines and gut microbiota in metabolic diseases.

There is accumulating evidence indicating the significant contribution of the gut microbiota to the herbal treatment of metabolic diseases. On the one hand, herbal medicines can improve metabolic diseases by increasing beneficial bacteria e.

On the other hand, gut microbes can metabolize and transform herbal compounds via glycoside hydrolase, oxidase, and reductase. These transformations may make herbs more bioavailable and bioactive or less toxic and thus benefit the treatment of metabolic diseases.

Despite advances in the research of herbal medicines and their effects on the gut microbiota, current studies are limited as they mostly rely on 16S rRNA sequencing technology to detect gut microbes, which has resulted in observations of the effects of herbal medicines on the gut microbiota at the family or genus level.

Moreover, current studies on the metabolism of herbal compounds by gut microbes are limited to one or a small class of components, and further analysis of more chemical compositions is needed to gain a better understanding of the overall impact of gut microbiota on herbal medicines.

Overall, the recent research progress in the interaction between herbal medicines and gut microbiota in metabolic diseases is encouraging. A comprehensive understanding of these interactions will help reveal the therapeutic mechanisms of herbal medicines.

LiW and XG conducted the review and wrote the manuscript. YD, JL, YuW, and YaW searched and collated the references. JZ revised the manuscript.

LD, WP, and GF conceived and designed the review. The authors gratefully acknowledge the financial support from the Key Research and Development Program of Sichuan Province No. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors, and the reviewers.

Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed, or endorsed by the publisher.

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Globally, Warrior diet exercise intensity diseases Leafy green market becoming Leafy green market major public health Herbak. Herbal medicines are medicinal metabolims or preparations derived from plants metsbolism Herbal metabolism regulator widely used in the treatment of metabolic diseases due to their good curative effects and minimal side effects. Recent studies have shown that gut microbiota plays an important role in the herbal treatment of metabolic diseases. However, the mechanisms involved are still not fully understood. This review provides a timely and comprehensive summary of the interactions between herbal medicines and gut microbiota in metabolic diseases. Mechanisms by which herbal medicines treat metabolic diseases include their effects on the gut microbial composition, the intestinal barrier, inflammation, and microbial metabolites e. Herbal metabolism regulator

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  1. Ich tue Abbitte, dass sich eingemischt hat... Aber mir ist dieses Thema sehr nah. Schreiben Sie in PM.

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